[et_pb_section fb_built=”1″ disabled_on=”on|on|on” admin_label=”Programs T- Hero Section” module_class=”hero tert” _builder_version=”4.18.0″ _module_preset=”default” background_image=”https:\/\/aafa.org\/wp-content\/uploads\/2022\/07\/AAFA-Website_Tertiary_Programs.jpg” background_position=”top_right” custom_padding=”1%||1%||true|false” global_module=”1619″ saved_tabs=”all” collapsed=”on” global_colors_info=”{}”][et_pb_row _builder_version=”4.17.4″ _module_preset=”default” background_enable_image=”off” background_size=”initial” background_position=”bottom_left” background_horizontal_offset=”0%” custom_margin=”||||false|false” custom_padding=”2%||0px||false|false” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text admin_label=”Nav Parent Title” module_class=”tert-parent” _builder_version=”4.17.4″ _module_preset=”default” header_2_font=”|600|||||||” header_2_text_align=”left” header_2_text_color=”#FFFFFF” header_2_font_size=”32px” custom_margin=”||0px||false|false” global_colors_info=”{}”]<\/p>\n
[\/et_pb_text][et_pb_code admin_label=”Breadcrumbs” module_class=”bcrumb” _builder_version=”4.17.4″ _module_preset=”default” text_orientation=”left” custom_margin=”||||false|false” custom_padding=”||||false|false” custom_css_main_element=”font-size:16px;||color: #fff;” global_colors_info=”{}”][\/et_pb_code][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Main Content” _builder_version=”4.21.0″ _module_preset=”default” custom_padding=”2%||2%||true|false” custom_css_main_element=”padding-top: 0 !important;” global_colors_info=”{}”][et_pb_row column_structure=”1_6,1_6,1_6,1_6,1_6,1_6″ admin_label=”Sticky Navigation” module_class=”sticky-menu” _builder_version=”4.21.0″ _module_preset=”default” background_color=”#692D87″ sticky_position=”top” motion_trigger_start=”bottom” global_colors_info=”{}”][et_pb_column type=”1_6″ _builder_version=”4.20.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text admin_label=”What is Type 2 Inflammation” _builder_version=”4.21.0″ _module_preset=”default” text_font=”||||||||” text_text_color=”#FFFFFF” text_font_size=”16px” text_orientation=”center” background_layout=”dark” module_alignment=”center” link_option_url=”#what-is-t2i” global_colors_info=”{}”]<\/p>\n
What is Type 2 Inflammation?<\/p>\n
[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_6″ _builder_version=”4.20.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text admin_label=”Who Experiences It” _builder_version=”4.21.0″ _module_preset=”default” text_font=”||||||||” text_text_color=”#FFFFFF” text_font_size=”16px” text_orientation=”center” module_alignment=”center” link_option_url=”#who-experiences-t2i” global_colors_info=”{}”]<\/p>\n
Who Experiences It?<\/p>\n
[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_6″ _builder_version=”4.20.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text admin_label=”More About It” _builder_version=”4.21.0″ _module_preset=”default” text_font=”||||||||” text_text_color=”#FFFFFF” text_font_size=”16px” module_alignment=”center” link_option_url=”#more-about-t2i” global_colors_info=”{}”]<\/p>\n
More About It<\/p>\n
[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_6″ _builder_version=”4.20.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text admin_label=”Connected Diseases” _builder_version=”4.21.0″ _module_preset=”default” text_font=”||||||||” text_text_color=”#FFFFFF” text_font_size=”16px” text_orientation=”center” background_layout=”dark” module_alignment=”center” link_option_url=”#connected-diseases” global_colors_info=”{}”]<\/p>\n
Connected Diseases<\/p>\n
[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_6″ _builder_version=”4.20.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text admin_label=”Shared Challenges” _builder_version=”4.21.0″ _module_preset=”default” text_font=”||||||||” text_text_color=”#FFFFFF” text_font_size=”16px” text_orientation=”center” background_layout=”dark” module_alignment=”center” link_option_url=”#shared-challenges” global_colors_info=”{}”]<\/p>\n
Shared Challenges<\/p>\n
[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_6″ _builder_version=”4.20.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_button button_url=”#play-the-game” button_text=”Play Game” button_alignment=”center” admin_label=”Play Game Button” _builder_version=”4.22.2″ _module_preset=”default” custom_button=”on” button_text_size=”18px” button_text_color=”#FFFFFF” button_bg_color=”#28BDBA” button_border_color=”#28BDBA” button_use_icon=”off” background_layout=”dark” custom_padding=”||||false|true” global_colors_info=”{}”][\/et_pb_button][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”2_3,1_3″ _builder_version=”4.20.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”2_3″ _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_post_title meta=”off” featured_image=”off” disabled_on=”on|on|on” admin_label=”Page Title” module_class=”tert-content” _builder_version=”4.17.4″ _module_preset=”default” title_font=”|600|||||||” title_text_align=”left” title_text_color=”#008c99″ title_font_size=”39px” background_enable_image=”off” background_size=”contain” background_position=”center_left” module_alignment=”left” custom_margin=”||0px||false|false” custom_padding=”||||false|false” disabled=”on” global_colors_info=”{}”][\/et_pb_post_title][et_pb_text admin_label=” Intro Content – What is T2I” module_id=”what-is-t2i” module_class=”secondary-intro” _builder_version=”4.22.2″ _module_preset=”default” text_text_color=”#505050″ text_font_size=”24px” text_line_height=”1.5em” header_2_font=”|600|||||||” header_2_text_color=”#008c99″ header_2_font_size=”39px” custom_margin=”||3%||false|false” global_colors_info=”{}”]<\/p>\n
Everyone has something called a type 2 immune response.<\/span><\/span>1<\/sup> A type 2 immune response typically happens when your body senses certain kinds of infections or allergens and sends out specific type 2 immune cells to fight a battle against the intruders by creating inflammation.<\/span><\/span>1,2<\/sup>\u00a0<\/span><\/p>\n [\/et_pb_text][et_pb_text admin_label=”Page Content” module_class=”secondary-intro” _builder_version=”4.22.2″ _module_preset=”default” text_text_color=”#505050″ text_line_height=”1.5em” header_2_font=”|600|||||||” header_2_text_color=”#008c99″ header_2_font_size=”39px” header_3_font_size=”28px” custom_margin=”||3%||false|false” global_colors_info=”{}”]<\/p>\n In some people, the immune cells cause inflammation even when there\u2019s no infection.1<\/sup> By doing so, they end up damaging the body itself. This is an overactive immune response called type 2 inflammation<\/strong>.1<\/sup><\/p>\n <\/p>\n Conditions such as atopic dermatitis and asthma, among others are caused in part by type 2 inflammation.1<\/sup><\/p>\n <\/p>\n Type 2 inflammation can be a chronic condition.1<\/sup> This means it always exists in the body, even when you don\u2019t feel or show symptoms.1<\/sup><\/p>\n <\/p>\n Scientists discovered type 2 inflammation in the 1980s and they\u2019re learning more and more about it every day.2,3,4<\/sup> It is now understood that type 2 inflammation plays a role in several diseases.2<\/sup> There is current and ongoing research to find out if this inflammatory process may contribute to even more diseases.2<\/sup><\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/aafa.org\/wp-content\/uploads\/2023\/10\/Quiz-jpg.webp” alt=”Icons os questions marks with the text text your knowledge see how much you know about type 2 inflammation by taking our quiz” title_text=”Quiz-jpg” url=”\/programs\/collaborations\/type-2-inflammation\/test-your-knowledge\/” disabled_on=”off|off|off” admin_label=”Test Your Knowlege Image” _builder_version=”4.22.2″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][et_pb_button button_url=”\/programs\/collaborations\/type-2-inflammation\/test-your-knowledge\/” button_text=”Take the Quiz” button_alignment=”center” disabled_on=”off|off|off” admin_label=”Take the Quiz” _builder_version=”4.22.2″ _module_preset=”default” custom_button=”on” button_text_color=”#FFFFFF” button_bg_color=”#28bdba” button_font=”|600|||||||” button_use_icon=”off” custom_css_main_element=”width:100%;” saved_tabs=”all” global_colors_info=”{}” button_text__hover_enabled=”off|desktop”][\/et_pb_button][\/et_pb_column][\/et_pb_row][et_pb_row admin_label=”Row – no sidebar” _builder_version=”4.20.4″ _module_preset=”default” custom_margin=”-75px||||false|false” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.20.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text admin_label=”Who Experiences T2I” module_id=”who-experiences-t2i” module_class=”secondary-intro” _builder_version=”4.21.0″ _module_preset=”default” text_text_color=”#505050″ text_line_height=”1.5em” header_2_font=”|600|||||||” header_2_text_color=”#008c99″ header_2_font_size=”39px” header_3_font_size=”28px” custom_margin=”||3%||false|false” global_colors_info=”{}”]<\/p>\n Diseases driven in part by type 2 inflammation may be diagnosed in childhood, but can develop at any age, impacting people for years, or even their entire lives.5,6,7<\/sup> Type 2 inflammation may contribute to a wide range of different diseases.1<\/sup><\/p>\n [\/et_pb_text][et_pb_toggle title=”Asthma” open_toggle_text_color=”#FFFFFF” open_toggle_background_color=”#f0f0f0″ closed_toggle_text_color=”#FFFFFF” closed_toggle_background_color=”#f0f0f0″ icon_color=”#FFFFFF” toggle_icon=”L||divi||400″ use_icon_font_size=”on” icon_font_size=”20px” open_icon_color=”#FFFFFF” open_toggle_icon=”K||divi||400″ open_use_icon_font_size=”on” open_icon_font_size=”20px” disabled_on=”off|off|off” admin_label=”Asthma” module_class=”accord” _builder_version=”4.21.0″ _module_preset=”default” title_text_color=”#FFFFFF” title_font=”|600|||||||” title_text_align=”left” title_font_size=”22px” closed_title_font=”|600|||||||” closed_title_text_align=”left” closed_title_font_size=”22px” closed_title_line_height=”1em” body_text_color=”#505050″ body_font_size=”16px” text_orientation=”left” width_tablet=”” width_phone=”” width_last_edited=”on|phone” max_width_tablet=”” max_width_phone=”” max_width_last_edited=”on|tablet” height=”258″ custom_margin=”||2%||false|false” custom_padding=”0px|0px|0px|0px|true|true” saved_tabs=”all” global_colors_info=”{}”]<\/p>\n [\/et_pb_toggle][et_pb_toggle title=”Atopic Dermatitis (AD)” open_toggle_text_color=”#FFFFFF” open_toggle_background_color=”#f0f0f0″ closed_toggle_text_color=”#FFFFFF” closed_toggle_background_color=”#f0f0f0″ icon_color=”#FFFFFF” toggle_icon=”L||divi||400″ use_icon_font_size=”on” icon_font_size=”20px” open_icon_color=”#FFFFFF” open_toggle_icon=”K||divi||400″ open_use_icon_font_size=”on” open_icon_font_size=”20px” disabled_on=”off|off|off” admin_label=”Atopic Derm” module_class=”accord” _builder_version=”4.21.0″ _module_preset=”default” title_text_color=”#FFFFFF” title_font=”|600|||||||” title_text_align=”left” title_font_size=”22px” closed_title_font=”|600|||||||” closed_title_text_align=”left” closed_title_font_size=”22px” closed_title_line_height=”1em” body_text_color=”#505050″ body_font_size=”16px” text_orientation=”left” width_tablet=”” width_phone=”” width_last_edited=”on|phone” max_width_tablet=”” max_width_phone=”” max_width_last_edited=”on|tablet” height=”258″ custom_margin=”||2%||false|false” custom_padding=”0px|0px|0px|0px|true|true” saved_tabs=”all” global_colors_info=”{}”]<\/p>\n [\/et_pb_toggle][et_pb_toggle title=”Nasal Polyps (NP), or Chronic Rhinosinusitis with Nasal Polyposis (CRSwNP)” open_toggle_text_color=”#FFFFFF” open_toggle_background_color=”#f0f0f0″ closed_toggle_text_color=”#FFFFFF” closed_toggle_background_color=”#f0f0f0″ icon_color=”#FFFFFF” toggle_icon=”L||divi||400″ use_icon_font_size=”on” icon_font_size=”20px” open_icon_color=”#FFFFFF” open_toggle_icon=”K||divi||400″ open_use_icon_font_size=”on” open_icon_font_size=”20px” disabled_on=”off|off|off” admin_label=”Nasal Polyps” module_class=”accord” _builder_version=”4.21.0″ _module_preset=”default” title_text_color=”#FFFFFF” title_font=”|600|||||||” title_text_align=”left” title_font_size=”22px” closed_title_font=”|600|||||||” closed_title_text_align=”left” closed_title_font_size=”22px” closed_title_line_height=”1em” body_text_color=”#505050″ body_font_size=”16px” text_orientation=”left” width_tablet=”” width_phone=”” width_last_edited=”on|phone” max_width_tablet=”” max_width_phone=”” max_width_last_edited=”on|tablet” height=”258″ custom_margin=”||2%||false|false” custom_padding=”0px|0px|0px|0px|true|true” saved_tabs=”all” global_colors_info=”{}”]<\/p>\n [\/et_pb_toggle][et_pb_toggle title=”Eosinophilic Esophagitis (EoE)” open_toggle_text_color=”#FFFFFF” open_toggle_background_color=”#f0f0f0″ closed_toggle_text_color=”#FFFFFF” closed_toggle_background_color=”#f0f0f0″ icon_color=”#FFFFFF” toggle_icon=”L||divi||400″ use_icon_font_size=”on” icon_font_size=”20px” open_icon_color=”#FFFFFF” open_toggle_icon=”K||divi||400″ open_use_icon_font_size=”on” open_icon_font_size=”20px” disabled_on=”off|off|off” admin_label=”EoE” module_class=”accord” _builder_version=”4.21.0″ _module_preset=”default” title_text_color=”#FFFFFF” title_font=”|600|||||||” title_text_align=”left” title_font_size=”22px” closed_title_font=”|600|||||||” closed_title_text_align=”left” closed_title_font_size=”22px” closed_title_line_height=”1em” body_text_color=”#505050″ body_font_size=”16px” text_orientation=”left” width_tablet=”” width_phone=”” width_last_edited=”on|phone” max_width_tablet=”” max_width_phone=”” max_width_last_edited=”on|tablet” height=”258″ custom_margin=”||2%||false|false” custom_padding=”0px|0px|0px|0px|true|true” saved_tabs=”all” global_colors_info=”{}”]<\/p>\n [\/et_pb_toggle][et_pb_toggle title=”Prurigo Nodularis (PN)” open_toggle_text_color=”#FFFFFF” open_toggle_background_color=”#f0f0f0″ closed_toggle_text_color=”#FFFFFF” closed_toggle_background_color=”#f0f0f0″ icon_color=”#FFFFFF” toggle_icon=”L||divi||400″ use_icon_font_size=”on” icon_font_size=”20px” open_icon_color=”#FFFFFF” open_toggle_icon=”K||divi||400″ open_use_icon_font_size=”on” open_icon_font_size=”20px” disabled_on=”off|off|off” admin_label=”Prurigo Nodularis” module_class=”accord” _builder_version=”4.21.0″ _module_preset=”default” title_text_color=”#FFFFFF” title_font=”|600|||||||” title_text_align=”left” title_font_size=”22px” closed_title_font=”|600|||||||” closed_title_text_align=”left” closed_title_font_size=”22px” closed_title_line_height=”1em” body_text_color=”#505050″ body_font_size=”16px” text_orientation=”left” width_tablet=”” width_phone=”” width_last_edited=”on|phone” max_width_tablet=”” max_width_phone=”” max_width_last_edited=”on|tablet” height=”258″ custom_margin=”||2%||false|false” custom_padding=”0px|0px|0px|0px|true|true” saved_tabs=”all” global_colors_info=”{}”]<\/p>\n [\/et_pb_toggle][et_pb_toggle title=”Certain Food Allergies” open_toggle_text_color=”#FFFFFF” open_toggle_background_color=”#f0f0f0″ closed_toggle_text_color=”#FFFFFF” closed_toggle_background_color=”#f0f0f0″ icon_color=”#FFFFFF” toggle_icon=”L||divi||400″ use_icon_font_size=”on” icon_font_size=”20px” open_icon_color=”#FFFFFF” open_toggle_icon=”K||divi||400″ open_use_icon_font_size=”on” open_icon_font_size=”20px” disabled_on=”off|off|off” admin_label=”Food Allergies” module_class=”accord” _builder_version=”4.21.0″ _module_preset=”default” title_text_color=”#FFFFFF” title_font=”|600|||||||” title_text_align=”left” title_font_size=”22px” closed_title_font=”|600|||||||” closed_title_text_align=”left” closed_title_font_size=”22px” closed_title_line_height=”1em” body_text_color=”#505050″ body_font_size=”16px” text_orientation=”left” width_tablet=”” width_phone=”” width_last_edited=”on|phone” max_width_tablet=”” max_width_phone=”” max_width_last_edited=”on|tablet” height=”258″ custom_margin=”||2%||false|false” custom_padding=”0px|0px|0px|0px|true|true” saved_tabs=”all” global_colors_info=”{}”]<\/p>\n [\/et_pb_toggle][et_pb_text admin_label=”More About T2I and Allergic Conditions” module_id=”more-about-t2i” module_class=”secondary-intro” _builder_version=”4.22.2″ _module_preset=”default” text_text_color=”#505050″ text_line_height=”1.5em” header_2_font=”|600|||||||” header_2_text_color=”#008c99″ header_2_font_size=”39px” header_3_font_size=”28px” custom_margin=”||||false|false” global_colors_info=”{}”]<\/p>\n If you have an allergic condition or another condition caused in part by type 2 inflammation, understanding the underlying cause is important when speaking with your doctor to create the right treatment plan for you. There are a variety of treatment options available to help improve control of your disease – some examples include creams and ointments, inhalers (or puffers), immunotherapies, certain oral medications and biologics.10,17<\/sup><\/p>\n <\/p>\n Before talking to your doctor about what treatment options may be best for you, here are some additional things to know about allergic conditions or other conditions caused in part by type 2 inflammation.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ use_custom_gutter=”on” gutter_width=”2″ disabled_on=”off|off|off” _builder_version=”4.20.2″ _module_preset=”default” custom_padding=”||1%||false|false” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.20.2″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/aafa.org\/wp-content\/uploads\/2023\/08\/Family-History-Type-2-Inflammation-AAFA.png” alt=”image of a family running across the beach” title_text=”Family History Type 2 Inflammation” show_bottom_space=”off” align=”center” admin_label=”Family History – Image” _builder_version=”4.21.0″ _module_preset=”default” background_enable_image=”off” width=”100%” custom_margin=”0px||3%||false|false” custom_padding=”0px||0px||false|false” global_colors_info=”{}”][\/et_pb_image][et_pb_text admin_label=”Family History – Text” module_class=”secondary-intro” _builder_version=”4.22.2″ _module_preset=”default” text_text_color=”#505050″ text_line_height=”1.5em” header_2_font=”|600|||||||” header_2_text_color=”#008c99″ header_2_font_size=”39px” header_3_font_size=”28px” header_4_text_color=”#28BDBA” header_4_font_size=”26px” custom_margin=”||3%||false|false” global_colors_info=”{}”]<\/p>\n When multiple people in a family have the same \u2013 or different \u2013 allergic conditions, it could be a sign of type 2 inflammation.1<\/sup> Type 2 inflammation could be one reason why someone has AD, their mother has asthma, and their aunt has nasal polyps.1<\/sup>\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0\u00a0<\/em><\/p>\n [\/et_pb_text][et_pb_image src=”https:\/\/aafa.org\/wp-content\/uploads\/2023\/07\/family-2.png” alt=”A photo of a woman carrying a young girl in a field of dried grass.” title_text=”family-2″ show_bottom_space=”off” align=”center” admin_label=”Triggers – Image” _builder_version=”4.21.0″ _module_preset=”default” background_enable_image=”off” width=”100%” custom_margin=”0px||3%||false|false” custom_padding=”0px||0px||false|false” global_colors_info=”{}”][\/et_pb_image][et_pb_text admin_label=”Triggers – Text” module_class=”secondary-intro” _builder_version=”4.21.0″ _module_preset=”default” text_text_color=”#505050″ text_line_height=”1.5em” header_2_font=”|600|||||||” header_2_text_color=”#008c99″ header_2_font_size=”39px” header_3_font_size=”28px” header_4_text_color=”#28BDBA” header_4_font_size=”26px” custom_margin=”||3%||false|false” global_colors_info=”{}”]<\/p>\n Factors like allergens (such as pollen, mold, and dust mites), exercise, stress, weather, and pollutants (such as ozone and smoke) can trigger symptoms or cause them to get worse.19,20<\/sup>[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/aafa.org\/wp-content\/uploads\/2023\/07\/group.png” alt=”image of a family running across the beach” title_text=”group” show_bottom_space=”off” align=”center” admin_label=”Multiple Diseases – Image” _builder_version=”4.21.0″ _module_preset=”default” background_enable_image=”off” width=”100%” custom_margin=”0px||3%||false|false” custom_padding=”0px||0px||false|false” global_colors_info=”{}”][\/et_pb_image][et_pb_text admin_label=”Multiple Diseases – Text” module_class=”secondary-intro” _builder_version=”4.21.0″ _module_preset=”default” text_text_color=”#505050″ text_line_height=”1.5em” header_2_font=”|600|||||||” header_2_text_color=”#008c99″ header_2_font_size=”39px” header_3_font_size=”28px” header_4_text_color=”#28BDBA” header_4_font_size=”26px” custom_margin=”||3%||false|false” global_colors_info=”{}”]<\/p>\n Many people with one allergic disease may have another disease because of the same underlying type 2 inflammation.1<\/sup> Often, the more severe disease is diagnosed first.18<\/sup> It\u2019s important to manage and treat your allergic conditions to reduce the impact of inflammation.<\/p>\n [\/et_pb_text][et_pb_image src=”https:\/\/aafa.org\/wp-content\/uploads\/2023\/07\/medical.png” alt=”A photo of a female medical professional listing to a child’s chest.” title_text=”medical” show_bottom_space=”off” align=”center” admin_label=”Tests – Image” _builder_version=”4.21.0″ _module_preset=”default” background_enable_image=”off” width=”100%” custom_margin=”0px||3%||false|false” custom_padding=”0px||0px||false|false” global_colors_info=”{}”][\/et_pb_image][et_pb_text admin_label=”Tests – Text” module_class=”secondary-intro” _builder_version=”4.21.0″ _module_preset=”default” text_text_color=”#505050″ text_line_height=”1.5em” header_2_font=”|600|||||||” header_2_text_color=”#008c99″ header_2_font_size=”39px” header_3_font_size=”28px” header_4_text_color=”#28BDBA” header_4_font_size=”26px” custom_margin=”||3%||false|false” global_colors_info=”{}”]<\/p>\n Family history, clinical presentation, and environmental triggers are the best ways to spot allergic conditions, but for certain diseases, there are also diagnostic tests.19<\/sup> If you have asthma, ask your doctor about breath or blood tests to help identify what kind of inflammation you have.<\/em><\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”][t2ib_type_2_inflammation title=”What Diseases are Connected by Type 2 Inflammation?” headlevel=”2″ circle1label=”Asthma” circle1desc=”<\/p>\n Asthma is a common chronic disease where up to 84% of people have underlying type 2 inflammation in the lungs, making it hard to breathe.21<\/sup> Around 24% of adults with moderate-to-severe asthma have more than one disease caused in part by type 2 inflammation.18,22<\/sup><\/p>\n ” circle2label=”Nasal Polyps” circle2desc=”<\/p>\n Chronic rhinosinusitis with nasal polyps (CRSwNP) is a disease where approximately 82% of people have type 2 inflammation in the nasal passages.18<\/sup> About 36% of people with moderate-to-severe nasal polyps have more than one other type 2 inflammatory disease.18<\/sup><\/p>\n ” circle3label=”Prurigo Nodularis (PN)” circle3desc=”<\/p>\n About 71% of people with PN experience frequent itch.23<\/sup> Type 2 inflammation may play a part in this disease.1<\/sup><\/p>\n ” circle4label=”Atopic Dermatitis (AD)” circle4desc=”<\/p>\n AD is a chronic inflammatory skin disease where almost everyone has signs of type 2 inflammation.24<\/sup> About 46% of adults with moderate-to-severe AD have more than one allergic condition.18<\/sup><\/p>\n ” circle5label=”Food allergies” circle5desc=”<\/p>\n Type 2 inflammation may play a role in certain food allergies, such as allergies to peanut, egg, cow’s milk, or other foods.13<\/sup><\/p>\n ” circle6label=”Eosinophilic Esophagitis (EoE)” circle6desc=”<\/p>\n EoE is a disease with type 2 inflammation in the esophagus, making it hard to eat, swallow, and socialize.25<\/sup> About 75% of people with EoE also live with one other condition caused in part by type 2 inflammation.25<\/sup><\/p>\n ” circle7label=”Atopic Dermatitis and Asthma” circle7desc=”<\/p>\n Around 31% of adults with moderate-to-severe AD also have asthma, and around 10% of adults with moderate-to-severe asthma also have AD.18<\/sup><\/p>\n ” circle8label=”EoE and Food Allergies” circle8desc=”<\/p>\n Both EoE and food allergies can negatively impact a person’s relationship with food.13<\/sup> About 67% of people with EoE report having food allergies.13<\/sup><\/p>\n ” circle9label=”Asthma and Nasal Polyps” circle9desc=”<\/p>\n Around 17% of adults with moderate-to-severe asthma also have nasal polyps and around 46% of adults with moderate-to-severe nasal polyps have asthma, which can make breathing and daily activities difficult.18<\/sup><\/p>\n ” admin_label=”Connected Diseases” module_id=”connected-diseases” _builder_version=”4.22.2″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n While it’s possible to have only one disease, people with type 2 inflammation are more likely to have another, driven by the same inflammation.1<\/sup> It’s important to work with your doctor to treat conditions caused in part by type 2 inflammation.<\/p>\n [\/t2ib_type_2_inflammation][et_pb_text admin_label=”Puzzle” module_class=”secondary-intro” _builder_version=”4.21.0″ _module_preset=”default” text_text_color=”#505050″ text_line_height=”1.5em” header_2_font=”|600|||||||” header_2_text_color=”#008c99″ header_2_font_size=”39px” custom_margin=”||3%||false|false” global_colors_info=”{}”]<\/p>\n You can help uncover a type 2 inflammation connection. Play the game and answer the questions.\u00a0<\/span><\/p>\n With each answer, we get closer to better understanding and educating about type 2 inflammation.<\/p>\n [\/et_pb_text][t2ip_puzzle iframeurl=”https:\/\/t2igame.kinsta.cloud\/” module_id=”play-the-game” _builder_version=”4.21.0″ _module_preset=”default” global_colors_info=”{}”][\/t2ip_puzzle][\/et_pb_column][\/et_pb_row][et_pb_row admin_label=”Row” _builder_version=”4.21.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.21.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_text admin_label=”Shared Challenges – Content” module_id=”shared-challenges” module_class=”secondary-intro” _builder_version=”4.22.2″ _module_preset=”default” text_text_color=”#505050″ text_line_height=”1.5em” header_2_font=”|600|||||||” header_2_text_color=”#008c99″ header_2_font_size=”39px” header_3_font_size=”28px” custom_margin=”||3%||false|false” global_colors_info=”{}”]<\/p>\n People with different diseases driven in part by type 2 inflammation experience similar challenges. These experiences can impact even simple daily activities.<\/p>\n <\/p>\n If you experience any of the following challenges, it could be time for a change in how you manage conditions caused in part by type 2 inflammation. Start by understanding an underlying cause of your disease and having a detailed conversation with your health care provider. With the right diagnosis and treatment plan, you can manage your conditions.<\/p>\n [\/et_pb_text][et_pb_toggle title=”Absences” open_toggle_text_color=”#FFFFFF” open_toggle_background_color=”#f0f0f0″ closed_toggle_text_color=”#FFFFFF” closed_toggle_background_color=”#f0f0f0″ icon_color=”#FFFFFF” toggle_icon=”L||divi||400″ use_icon_font_size=”on” icon_font_size=”20px” open_icon_color=”#FFFFFF” open_toggle_icon=”K||divi||400″ open_use_icon_font_size=”on” open_icon_font_size=”20px” disabled_on=”off|off|off” admin_label=”Absences” module_class=”accord” _builder_version=”4.21.0″ _module_preset=”default” title_text_color=”#FFFFFF” title_font=”|600|||||||” title_text_align=”left” title_font_size=”22px” closed_title_font=”|600|||||||” closed_title_text_align=”left” closed_title_font_size=”22px” closed_title_line_height=”1em” body_text_color=”#505050″ body_font_size=”16px” text_orientation=”left” width_tablet=”” width_phone=”” width_last_edited=”on|phone” max_width_tablet=”” max_width_phone=”” max_width_last_edited=”on|tablet” height=”258″ custom_margin=”||2%||false|false” custom_padding=”0px|0px|0px|0px|true|true” saved_tabs=”all” global_colors_info=”{}”]<\/p>\n Because symptoms come and go unpredictably (and may disrupt sleep), conditions driven in part by type 2 inflammation may often cause you to miss work or school days or cause issues with productivity.10,29<\/sup><\/p>\n [\/et_pb_toggle][et_pb_toggle title=”Delays to Diagnosis and Treatment” open_toggle_text_color=”#FFFFFF” open_toggle_background_color=”#f0f0f0″ closed_toggle_text_color=”#FFFFFF” closed_toggle_background_color=”#f0f0f0″ icon_color=”#FFFFFF” toggle_icon=”L||divi||400″ use_icon_font_size=”on” icon_font_size=”20px” open_icon_color=”#FFFFFF” open_toggle_icon=”K||divi||400″ open_use_icon_font_size=”on” open_icon_font_size=”20px” disabled_on=”off|off|off” admin_label=”Delays to Diagnosis and Treatment” module_class=”accord” _builder_version=”4.21.0″ _module_preset=”default” title_text_color=”#FFFFFF” title_font=”|600|||||||” title_text_align=”left” title_font_size=”22px” closed_title_font=”|600|||||||” closed_title_text_align=”left” closed_title_font_size=”22px” closed_title_line_height=”1em” body_text_color=”#505050″ body_font_size=”16px” text_orientation=”left” width_tablet=”” width_phone=”” width_last_edited=”on|phone” max_width_tablet=”” max_width_phone=”” max_width_last_edited=”on|tablet” height=”258″ custom_margin=”||2%||false|false” custom_padding=”0px|0px|0px|0px|true|true” saved_tabs=”all” global_colors_info=”{}”]<\/p>\n Many people who have conditions driven in part by type 2 inflammation have a hard time getting diagnosed or finding the right specialist.10,13,19,29<\/sup> This can make the road to effective treatment longer and more difficult to manage.10,13,19,29<\/sup><\/p>\n [\/et_pb_toggle][et_pb_toggle title=”Emotional Challenges” open_toggle_text_color=”#FFFFFF” open_toggle_background_color=”#f0f0f0″ closed_toggle_text_color=”#FFFFFF” closed_toggle_background_color=”#f0f0f0″ icon_color=”#FFFFFF” toggle_icon=”L||divi||400″ use_icon_font_size=”on” icon_font_size=”20px” open_icon_color=”#FFFFFF” open_toggle_icon=”K||divi||400″ open_use_icon_font_size=”on” open_icon_font_size=”20px” disabled_on=”off|off|off” admin_label=”Emotional Challenges” module_class=”accord” _builder_version=”4.21.0″ _module_preset=”default” title_text_color=”#FFFFFF” title_font=”|600|||||||” title_text_align=”left” title_font_size=”22px” closed_title_font=”|600|||||||” closed_title_text_align=”left” closed_title_font_size=”22px” closed_title_line_height=”1em” body_text_color=”#505050″ body_font_size=”16px” text_orientation=”left” width_tablet=”” width_phone=”” width_last_edited=”on|phone” max_width_tablet=”” max_width_phone=”” max_width_last_edited=”on|tablet” height=”258″ custom_margin=”||2%||false|false” custom_padding=”0px|0px|0px|0px|true|true” saved_tabs=”all” global_colors_info=”{}”]<\/p>\n The challenges aren\u2019t always physical.10,17,29<\/sup> Many people with conditions driven in part by type 2 inflammation experience anxiety, stress, depression, and an overall lack of confidence.10,17,29<\/sup><\/p>\n [\/et_pb_toggle][et_pb_toggle title=”Isolation” open_toggle_text_color=”#FFFFFF” open_toggle_background_color=”#f0f0f0″ closed_toggle_text_color=”#FFFFFF” closed_toggle_background_color=”#f0f0f0″ icon_color=”#FFFFFF” toggle_icon=”L||divi||400″ use_icon_font_size=”on” icon_font_size=”20px” open_icon_color=”#FFFFFF” open_toggle_icon=”K||divi||400″ open_use_icon_font_size=”on” open_icon_font_size=”20px” disabled_on=”off|off|off” admin_label=”Isolation” module_class=”accord” _builder_version=”4.21.0″ _module_preset=”default” title_text_color=”#FFFFFF” title_font=”|600|||||||” title_text_align=”left” title_font_size=”22px” closed_title_font=”|600|||||||” closed_title_text_align=”left” closed_title_font_size=”22px” closed_title_line_height=”1em” body_text_color=”#505050″ body_font_size=”16px” text_orientation=”left” width_tablet=”” width_phone=”” width_last_edited=”on|phone” max_width_tablet=”” max_width_phone=”” max_width_last_edited=”on|tablet” height=”258″ custom_margin=”||2%||false|false” custom_padding=”0px|0px|0px|0px|true|true” saved_tabs=”all” global_colors_info=”{}”]<\/p>\n Feelings of embarrassment and misunderstanding can make people with conditions driven in part by type 2 inflammation feel alone and isolated.10,17,29<\/sup><\/p>\n [\/et_pb_toggle][et_pb_toggle title=”Limitations in Daily Life” open_toggle_text_color=”#FFFFFF” open_toggle_background_color=”#f0f0f0″ closed_toggle_text_color=”#FFFFFF” closed_toggle_background_color=”#f0f0f0″ icon_color=”#FFFFFF” toggle_icon=”L||divi||400″ use_icon_font_size=”on” icon_font_size=”20px” open_icon_color=”#FFFFFF” open_toggle_icon=”K||divi||400″ open_use_icon_font_size=”on” open_icon_font_size=”20px” disabled_on=”off|off|off” admin_label=”Limitations in Daily Life” module_class=”accord” _builder_version=”4.21.0″ _module_preset=”default” title_text_color=”#FFFFFF” title_font=”|600|||||||” title_text_align=”left” title_font_size=”22px” closed_title_font=”|600|||||||” closed_title_text_align=”left” closed_title_font_size=”22px” closed_title_line_height=”1em” body_text_color=”#505050″ body_font_size=”16px” text_orientation=”left” width_tablet=”” width_phone=”” width_last_edited=”on|phone” max_width_tablet=”” max_width_phone=”” max_width_last_edited=”on|tablet” height=”258″ custom_margin=”||2%||false|false” custom_padding=”0px|0px|0px|0px|true|true” saved_tabs=”all” global_colors_info=”{}”]<\/p>\n When conditions driven in part by type 2 inflammation are not well-controlled, daily activities may be more difficult, including sports, chores, hobbies, school, work, and social activities.10,17,29<\/sup><\/p>\n [\/et_pb_toggle][et_pb_toggle title=”Risk of Hospital Stays” open_toggle_text_color=”#FFFFFF” open_toggle_background_color=”#f0f0f0″ closed_toggle_text_color=”#FFFFFF” closed_toggle_background_color=”#f0f0f0″ icon_color=”#FFFFFF” toggle_icon=”L||divi||400″ use_icon_font_size=”on” icon_font_size=”20px” open_icon_color=”#FFFFFF” open_toggle_icon=”K||divi||400″ open_use_icon_font_size=”on” open_icon_font_size=”20px” disabled_on=”off|off|off” admin_label=”Risk of Hospital Stays” module_class=”accord” _builder_version=”4.22.2″ _module_preset=”default” title_text_color=”#FFFFFF” title_font=”|600|||||||” title_text_align=”left” title_font_size=”22px” closed_title_font=”|600|||||||” closed_title_text_align=”left” closed_title_font_size=”22px” closed_title_line_height=”1em” body_text_color=”#505050″ body_font_size=”16px” text_orientation=”left” width_tablet=”” width_phone=”” width_last_edited=”on|phone” max_width_tablet=”” max_width_phone=”” max_width_last_edited=”on|tablet” height=”258″ custom_margin=”||2%||false|false” custom_padding=”0px|0px|0px|0px|true|true” saved_tabs=”all” global_colors_info=”{}”]<\/p>\n Sometimes symptom flares aren\u2019t just flares – they may be life-threatening.10,16<\/sup> A hospital visit is a real concern and can happen unpredictably.10<\/sup><\/p>\n [\/et_pb_toggle][et_pb_toggle title=”Sleep Issues” open_toggle_text_color=”#FFFFFF” open_toggle_background_color=”#f0f0f0″ closed_toggle_text_color=”#FFFFFF” closed_toggle_background_color=”#f0f0f0″ icon_color=”#FFFFFF” toggle_icon=”L||divi||400″ use_icon_font_size=”on” icon_font_size=”20px” open_icon_color=”#FFFFFF” open_toggle_icon=”K||divi||400″ open_use_icon_font_size=”on” open_icon_font_size=”20px” disabled_on=”off|off|off” admin_label=”Sleep Issues” module_class=”accord” _builder_version=”4.21.0″ _module_preset=”default” title_text_color=”#FFFFFF” title_font=”|600|||||||” title_text_align=”left” title_font_size=”22px” closed_title_font=”|600|||||||” closed_title_text_align=”left” closed_title_font_size=”22px” closed_title_line_height=”1em” body_text_color=”#505050″ body_font_size=”16px” text_orientation=”left” width_tablet=”” width_phone=”” width_last_edited=”on|phone” max_width_tablet=”” max_width_phone=”” max_width_last_edited=”on|tablet” height=”258″ custom_margin=”||2%||false|false” custom_padding=”0px|0px|0px|0px|true|true” saved_tabs=”all” global_colors_info=”{}”]<\/p>\n Conditions driven in part by type 2 inflammation sometimes affect your sleep.10,36<\/sup> Uncontrolled symptoms can make it hard for you to fall asleep or stay asleep.10,36<\/sup><\/p>\n [\/et_pb_toggle][et_pb_toggle title=”Treatment Burdens” open_toggle_text_color=”#FFFFFF” open_toggle_background_color=”#f0f0f0″ closed_toggle_text_color=”#FFFFFF” closed_toggle_background_color=”#f0f0f0″ icon_color=”#FFFFFF” toggle_icon=”L||divi||400″ use_icon_font_size=”on” icon_font_size=”20px” open_icon_color=”#FFFFFF” open_toggle_icon=”K||divi||400″ open_use_icon_font_size=”on” open_icon_font_size=”20px” disabled_on=”off|off|off” admin_label=”Treatment Burdens” module_class=”accord” _builder_version=”4.21.0″ _module_preset=”default” title_text_color=”#FFFFFF” title_font=”|600|||||||” title_text_align=”left” title_font_size=”22px” closed_title_font=”|600|||||||” closed_title_text_align=”left” closed_title_font_size=”22px” closed_title_line_height=”1em” body_text_color=”#505050″ body_font_size=”16px” text_orientation=”left” width_tablet=”” width_phone=”” width_last_edited=”on|phone” max_width_tablet=”” max_width_phone=”” max_width_last_edited=”on|tablet” height=”258″ custom_margin=”||2%||false|false” custom_padding=”0px|0px|0px|0px|true|true” saved_tabs=”all” global_colors_info=”{}”]<\/p>\n Certain treatments prescribed for conditions driven in part by type 2 inflammation can help relieve symptoms, like steroids and immunosuppressants.10,37<\/sup> But some options can sometimes have negative long-term effects.10,37<\/sup><\/p>\n [\/et_pb_toggle][et_pb_toggle title=”Unpredictability” open_toggle_text_color=”#FFFFFF” open_toggle_background_color=”#f0f0f0″ closed_toggle_text_color=”#FFFFFF” closed_toggle_background_color=”#f0f0f0″ icon_color=”#FFFFFF” toggle_icon=”L||divi||400″ use_icon_font_size=”on” icon_font_size=”20px” open_icon_color=”#FFFFFF” open_toggle_icon=”K||divi||400″ open_use_icon_font_size=”on” open_icon_font_size=”20px” disabled_on=”off|off|off” admin_label=”Unpredictability” module_class=”accord” _builder_version=”4.21.0″ _module_preset=”default” title_text_color=”#FFFFFF” title_font=”|600|||||||” title_text_align=”left” title_font_size=”22px” closed_title_font=”|600|||||||” closed_title_text_align=”left” closed_title_font_size=”22px” closed_title_line_height=”1em” body_text_color=”#505050″ body_font_size=”16px” text_orientation=”left” width_tablet=”” width_phone=”” width_last_edited=”on|phone” max_width_tablet=”” max_width_phone=”” max_width_last_edited=”on|tablet” height=”258″ custom_margin=”||2%||false|false” custom_padding=”0px|0px|0px|0px|true|true” saved_tabs=”all” global_colors_info=”{}”]<\/p>\n From symptom flare-ups to life-threatening attacks, conditions driven in part by type 2 inflammation can be very unpredictable.10,16,29<\/sup><\/p>\n [\/et_pb_toggle][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.21.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.21.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_text admin_label=”Medical Review \/ Sponsor” module_class=”med-rev clearfix” _builder_version=”4.22.2″ _module_preset=”default” text_text_color=”#505050″ text_font_size=”16px” link_text_color=”#008C99″ link_font_size=”16px” header_5_font=”|600|||||||” header_5_text_align=”left” header_5_text_color=”#008c99″ custom_margin=”||3%||false|false” global_colors_info=”{}”]<\/p>\n The health information contained herein is provided for general educational purposes only. Your healthcare professional is the best source of information regarding your health. Please consult your healthcare professional if you have any questions about your health or treatment.<\/span><\/i><\/p>\n <\/p>\n AAFA medical review: June 2023 <\/span>by <\/span>John James, MD<\/span><\/span>\u00a0<\/span><\/p>\n <\/p>\n This content is supported by Sanofi and Regeneron. <\/em><\/p>\n US.IMM.23.09.0006 | September 2023<\/p>\n [\/et_pb_text][et_pb_toggle title=”References” toggle_icon=”P||divi||400″ open_toggle_icon=”O||divi||400″ admin_label=”References Toggle” _builder_version=”4.22.2″ _module_preset=”059b4522-dcda-4db5-bd19-de655dc7f194″ body_font_size=”16px” global_colors_info=”{}”]<\/p>\n 1<\/sup> Gandhi, N. A., Bennett, B. L., Graham, N. M., Pirozzi, G., Stahl, N., & Yancopoulos, G. D. (2015). Targeting key proximal drivers of type 2 inflammation in disease. Nature Reviews Drug Discovery<\/em>, 15<\/em>(1), 35\u201350. https:\/\/doi.org\/10.1038\/nrd4624<\/a><\/p>\n 2<\/sup> Gandhi NA, Pirozzi G, Graham NM. Commonality of the IL-4\/IL-13 pathway in atopic diseases. Expert review ofclinical immunology. 2017 May 4;13(5):425-37. https:\/\/doi.org\/10.1080\/1744666X.2017.1298443<\/a><\/p>\n 3<\/sup> Mosmann, T. R., Cherwinski, H., Bond, M. W., Giedlin, M. A., & Coffman, R. L. (1986). Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. The Journal of Immunology<\/em>, 136<\/em>(7), 2348\u20132357. https:\/\/doi.org\/10.4049\/jimmunol.136.7.2348<\/a><\/p>\n 4<\/sup> Snapper, C. M., Finkelman, F. D., & Paul, W. E. (1988). Regulation of IGG1 and IGE production by interleukin 4. Immunological Reviews<\/em>, 102<\/em>(1), 51\u201375. https:\/\/doi.org\/10.1111\/j.1600-065x.1988.tb00741.x<\/a><\/p>\n 5<\/sup> Huang, E., & Ong, P. Y. (2018). Severe atopic dermatitis in children. Current Allergy and Asthma Reports<\/em>, 18<\/em>(6). https:\/\/doi.org\/10.1007\/s11882-018-0788-4<\/a><\/p>\n 6<\/sup> von Mutius, E. (2000). The burden of childhood asthma. Archives of Disease in Childhood<\/em>, 82<\/em>(90002), 2ii\u20135. https:\/\/doi.org\/10.1136\/adc.82.suppl_2.ii2<\/a><\/p>\n 7<\/sup> Menard-Katcher, P., Marks, K. L., Liacouras, C. A., Spergel, J. M., Yang, Y.-X., & Falk, G. W. (2012). The natural history of eosinophilic oesophagitis in the transition from childhood to adulthood. Alimentary Pharmacology & Therapeutics<\/em>, 37<\/em>(1), 114\u2013121. https:\/\/doi.org\/10.1111\/apt.12119<\/a><\/p>\n 8<\/sup> Krishnan, J. A., Cloutier, M. M., & Schatz, M. (2021). National Asthma Education and prevention program 2020 guideline update: Where do we go from here? American Journal of Respiratory and Critical Care Medicine<\/em>, 203<\/em>(2), 164\u2013167. https:\/\/doi.org\/10.1164\/rccm.202011-4236ed<\/a><\/p>\n 9<\/sup>What is atopic dermatitis and how can I tell if I have it?<\/i>. National Eczema Association. (2021, December 2). https:\/\/nationaleczema.org\/eczema\/types-of-eczema\/atopic-dermatitis\/<\/span><\/a><\/p>\n 10<\/sup> Fokkens, W. J., Lund, V. J., Hopkins, C., Hellings, P. W., Kern, R., Reitsma, S., Toppila-Salmi, S., Bernal-Sprekelsen, M., Mullol, J., Alobid, I., Terezinha Anselmo-Lima, W., Bachert, C., Baroody, F., von Buchwald, C., Cervin, A., Cohen, N., Constantinidis, J., De Gabory, L., Desrosiers, M., \u2026 Zwetsloot, C. P. (2020). European position paper on Rhinosinusitis and nasal polyps 2020. Rhinology Journal<\/em>, 0<\/em>(0), 1\u2013464. https:\/\/doi.org\/10.4193\/rhin20.600<\/a><\/p>\n 11<\/sup> Nordin, S., Hed\u00e9n Blomqvist, E., Olsson, P., Stj\u00e4rne, P., & Ehnhage, A. (2011). Effects of smell loss on daily life and adopted coping strategies in patients with nasal polyposis with asthma. Acta Oto-Laryngologica<\/em>, 131<\/em>(8), 826\u2013832. https:\/\/doi.org\/10.3109\/00016489.2010.539625<\/a><\/p>\n 12<\/sup> Hirano, I., Chan, E. S., Rank, M. A., Sharaf, R. N., Stollman, N. H., Stukus, D. R., Wang, K., Greenhawt, M., Falck-Ytter, Y. T., Chachu, K. A., Day, L., Lebwohl, B., Muniraj, T., Patel, A., Peery, A. F., Shah, R., Singh, H., Singh, S., Spechler, S. J., \u2026 Sharaf, R. (2020). Aga Institute and the Joint Task Force on allergy-immunology practice parameters clinical guidelines for the management of eosinophilic esophagitis. Annals of Allergy, Asthma & Immunology<\/em>, 124<\/em>(5), 416\u2013423. https:\/\/doi.org\/10.1016\/j.anai.2020.03.020<\/a><\/p>\n 13<\/sup> Chehade, M., Jones, S. M., Pesek, R. D., Burks, A. W., Vickery, B. P., Wood, R. A., Leung, D. Y. M., Furuta, G. T., Fleischer, D. M., Henning, A. K., Dawson, P., Lindblad, R. W., Sicherer, S. H., Abonia, J. P., Sherrill, J. D., Sampson, H. A., & Rothenberg, M. E. (2018). Phenotypic characterization of eosinophilic esophagitis in a large multicenter patient population from the Consortium for Food Allergy\u00a0Research. The Journal of Allergy and Clinical Immunology: In Practice<\/em>, 6<\/em>(5). https:\/\/doi.org\/10.1016\/j.jaip.2018.05.038<\/a><\/p>\n 14<\/sup>Lucendo AJ, et al. Guidelines on eosinophilic esophagitis: evidence-based statements and recommendations for diagnosis and management in children and adults. United European Gastroenterol J. 2017;5(3):335-358 https:\/\/doi.org\/10.1177\/2050640616689525<\/span><\/a><\/p>\n 15<\/sup>Kwatra, S. G. (2022). Prurigo nodularis. JAMA Dermatology<\/i>, 158<\/i>(3), 336. https:\/\/doi.org\/10.1001\/jamadermatol.2021.5307<\/span><\/a><\/p>\n 16<\/sup> Anaphylaxis: Taber\u2019s medical dictionary<\/em>. anaphylaxis | Taber\u2019s Medical Dictionary. (n.d.-b). https:\/\/www.tabers.com\/tabersonline\/view\/Tabers-Dictionary\/764253\/all\/anaphylaxis#:~:text=A%20sudden%2C%20severe%20allergic%20reaction,(late%2Dstage%20response)<\/a>.<\/p>\n 17<\/sup> Sidbury R, Davis DM, Cohen DE, Cordoro KM, Berger TG, Bergman JN, Chamlin SL, Cooper KD,Feldman SR, Hanifin JM, Krol A. Guidelines of care for the management of atopic dermatitis: section 3.Management and treatment with phototherapy and systemic agents. Journal of the American Academy of Dermatology. 2014 Aug 1;71(2):327-49. https:\/\/doi.org\/10.1177\/2050640616689525<\/a><\/p>\n 18<\/sup> Khan, A. H., Gouia, I., Kamat, S., Johnson, R., Small, M., & Siddall, J. (2023a). Prevalence and severity distribution of type 2 inflammation-related comorbidities among patients with asthma, chronic rhinosinusitis with nasal polyps, and atopic dermatitis. Lung<\/em>, 201<\/em>(1), 57\u201363. https:\/\/doi.org\/10.1007\/s00408-023-00603-z<\/a><\/p>\n 19<\/sup> (2018). GLOBAL STRATEGY FOR ASTHMA. MANAGEMENT AND PREVENTION. ONLINE APPENDIX. <\/em>https:\/\/ginasthma.org\/wp-content\/uploads\/2018\/03\/WMS-FINAL-GINA-2018-Appendix_v1.3.pdf<\/a><\/p>\n 20<\/sup>Sugita K, Kabashima K. Tight junctions in the development of asthma, chronic rhinosinusitis, atopic dermatitis, eosinophilic esophagitis, and inflammatory bowel diseases. Journal of leukocyte biology. 2020 May;107(5):749-62. https:\/\/doi.org\/10.1002\/JLB.5MR0120-230R<\/span><\/a><\/p>\n 21<\/sup> Krishnan, J. A., Cloutier, M. M., & Schatz, M. (2021). National Asthma Education and prevention program 2020 guideline update: Where do we go from here? American Journal of Respiratory and Critical Care Medicine<\/em>, 203<\/em>(2), 164\u2013167. https:\/\/doi.org\/10.1164\/rccm.202011-4236ed<\/a><\/p>\n 22<\/sup> Seys, S. F., Scheers, H., Van den Brande, P., Marijsse, G., Dilissen, E., Van Den Bergh, A., Goeminne, P. C., Hellings, P. W., Ceuppens, J. L., Dupont, L. J., & Bullens, D. M. (2017). Cluster analysis of sputum cytokine-high profiles reveals diversity in T(H)2-high asthma patients. Respiratory Research<\/em>, 18<\/em>(1). https:\/\/doi.org\/10.1186\/s12931-017-0524-y<\/a><\/p>\n 23<\/sup> Bewley, A., Homey, B., & Pink, A. (2022). Prurigo nodularis: A review of IL-31RA blockade and other potential treatments. Dermatology and Therapy<\/em>, 12<\/em>(9), 2039\u20132048. https:\/\/doi.org\/10.1007\/s13555-022-00782-2<\/a><\/p>\n 24<\/sup> Akdis, C. A., Arkwright, P. D., Br\u00fcggen, M.-C., Busse, W., Gadina, M., Guttman\u2010Yassky, E., Kabashima, K., Mitamura, Y., Vian, L., Wu, J., & Palomares, O. (2020). Type 2 immunity in the skin and lungs. Allergy<\/em>, 75<\/em>(7), 1582\u20131605. https:\/\/doi.org\/10.1111\/all.14318<\/a><\/p>\n 25<\/sup> van Rhijn, B. D., & Bredenoord, A. J. (2017). Management of eosinophilic esophagitis based on pathophysiological evidence. Journal of Clinical Gastroenterology<\/em>, 51<\/em>(8), 659\u2013668. https:\/\/doi.org\/10.1097\/mcg.0000000000000879<\/a><\/p>\n 26<\/sup> van Rheede, T., Bastiaans, T., Boone, D. N., Hedges, S. B., de Jong, W. W., & Madsen, O. (2005). The platypus is in its place: Nuclear genes and indels confirm the sister group relation of Monotremes and Therians. Molecular Biology and Evolution<\/em>, 23<\/em>(3), 587\u2013597. https:\/\/doi.org\/10.1093\/molbev\/msj064<\/a><\/p>\nDiseases Driven in Part by Type 2 Inflammation<\/h2>\n
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About Type 2 Inflammation and Allergic Conditions<\/h2>\n
Family History<\/h4>\n
Environmental and Physical Triggers<\/h4>\n
Multiple Diseases<\/h4>\n
Tests<\/h4>\n
Things aren\u2019t always as they seem. Sometimes, there is a hidden connection between different allergic diseases or those driven in part by type 2 inflammation. Managing multiple diseases can be challenging. Understanding the connection can change how you think. When you know how they are connected, you can work with your doctor to help find a treatment plan that could work for you.<\/h3>\n
Shared Challenges<\/h2>\n